Different Modulatory Effects of IL-17, IL-22, and IL-23 on Osteoblast Differentiation.

Jing-Ru ZhangDan-Dan PangQiang TongXia LiuDing-Feng SuSheng-Ming Dai

Published in: Mediators of inflammation (2017)

Primary osteoblasts constitutively express IL-17 receptors, but none of C2C12 cells, MC3T3-E1 cells, and Saos-2 cells express any receptors for IL-17, IL-22, and IL-23. IL-17 inhibits BMP-2-induced osteoblast differentiation via the BMP/Smad-independent pathway.

Keyphrases

induced apoptosis
cell cycle arrest
mesenchymal stem cells
oxidative stress
signaling pathway
high glucose
diabetic rats