NRN1 interacts with Notch to increase oncogenic STAT3 signaling in melanoma.
Lucia DevittDana WestphalKatharina PiegerNadja SchneiderAnja Katrin BosserhoffSilke KuphalPublished in: Cell communication and signaling : CCS (2024)
In summary, we were able to show that NRN1 links oncogenic signaling events between Notch and STAT3 in melanoma. We also suggest that in future research more attention should be payed to cellular regulation of signaling molecules outside of the classically known phosphorylation events.