Comparing Effects of Tolvaptan and Instruction to Increase Water Consumption in ADPKD: Post-hoc Analysis of TEMPO 3:4.

This analysis supports a relationship between effects on Uosm and inhibition of disease progression by tolvaptan and high water intake alone. The findings further suggest that 24-hour Uosm measurement is superior to spot Uosm for assessing suppression of vasopressin activity by tolvaptan.