Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404).

Hikaru KatoMomona SebeMika NagakiKeisuke EguchiIppei KagiyamaYuki HitoraJens C FrisvadRobert M WilliamsSachiko Tsukamoto

Published in: Journal of natural products (2019)

Four new norditerpenes, taichunins A-D (1-4), were isolated from the fungus Aspergillus taichungensis (IBT 19404). Compound 1 has a new carbon framework. The absolute configurations were determined by the calculated ECD spectral method. Compound 1 was cytotoxic against HeLa cells with an IC50 value of 4.5 μM, whereas 2-4 were nontoxic at 50 μM.

Keyphrases

cell cycle arrest
induced apoptosis
cell death
cell wall
pi k akt
computed tomography