Independent transcriptional patterns reveal biological processes associated with disease-free survival in early colorectal cancer.
Daan G KnapenSara Hone LopezDerk Jan A de GrootJacco-Juri de HaanElisabeth G E de VriesRodrigo DienstmannSteven de JongArkajyoti BhattacharyaRudolf S N FehrmannPublished in: Communications medicine (2024)
This finding indicates that early CRC may have nine distinct routes to achieve EMT, each requiring a specific peri-operative treatment strategy. Finally, we stratify patients into DFS patient subgroups with distinct transcriptional patterns associated with stage 2 and stage 3 CRC.
Keyphrases
- free survival
- end stage renal disease
- gene expression
- newly diagnosed
- ejection fraction
- transcription factor
- prognostic factors
- epithelial mesenchymal transition
- peritoneal dialysis
- case report
- genome wide
- patient reported outcomes
- single cell
- dna methylation
- combination therapy
- signaling pathway
- replacement therapy