Clinical and hormonal findings in patients presenting with high IGF-1 and growth hormone suppression after oral glucose load: a retrospective cohort study.
Giulia CarosiAlessandra MangoneElisa SalaGiulia Del SindacoRoberta MungariArianna CremaschiEmanuele FerranteMaura ArosioGiovanna MantovaniPublished in: European journal of endocrinology (2021)
In patients presenting high IGF-1 but GHn < 0.4 μg/L, a hormonal progression is improbable, likely excluding classical acromegaly in its early stage. However, despite persistently low GH nadir values, patients with acromegalic features present more acromegalic comorbidities whose rate increases over time. Close clinical surveillance of this group is advised.
Keyphrases
- growth hormone
- early stage
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- polycystic ovary syndrome
- prognostic factors
- peritoneal dialysis
- blood pressure
- radiation therapy
- adipose tissue
- cell proliferation
- skeletal muscle
- lymph node
- insulin resistance
- patient reported
- neoadjuvant chemotherapy