Bicuspid Aortic Valve Disease With Early Onset Complications: Characteristics And Aortic Outcomes.
Maximilian A SelbstMegan K LaughlinColin R WardHector MichelenaAnna Sabate-RotesLisa BiancoJulie De BackerLaura Muiño MosqueraAnji T YetmanMalenka M BissellMaria Grazia AndreassiIlenia FoffaDawn S HuiAnthony CaffarelliYuli Y KimDongchuan GuoRodolfo CitroMargot De MarcoJustin T TretterShaine A MorrisKim L McBrideSimon C Bodynull nullSiddharth K PrakashPublished in: medRxiv : the preprint server for health sciences (2024)
Bicuspid aortic valve (BAV) is the most common congenital heart malformation in adults but can also cause childhood-onset complications. In multicenter study, we found that adults who experience significant complications of BAV disease before age 30 are distinguished from the majority of BAV cases that manifest after age 50 by a relatively severe clinical course, with higher rates of surgical interventions, more frequent second interventions, and a greater burden of congenital heart malformations. These observations highlight the need for prompt recognition, regular lifelong surveillance, and targeted interventions to address the significant health burdens of patients with early onset BAV complications.
Keyphrases
- aortic valve
- early onset
- aortic stenosis
- transcatheter aortic valve replacement
- late onset
- aortic valve replacement
- transcatheter aortic valve implantation
- risk factors
- physical activity
- public health
- healthcare
- mental health
- heart failure
- type diabetes
- left ventricular
- skeletal muscle
- adipose tissue
- health information
- climate change
- health promotion
- drug induced
- glycemic control
- weight loss