Genetic determinants of steatosis and fibrosis progression in paediatric non-alcoholic fatty liver disease.

Christian A HudertSilvia SelinskiBirgit RudolphHendrik BläkerChristoph LoddenkemperRia ThielhornNikolaus BerndtKlaus GolkaCristina CadenasJörg ReindersStephan HenningPhilip BuflerPeter L M JansenHermann-Georg HolzhütterDavid MeierhoferJan G HengstlerSusanna Wiegand

Published in: Liver international : official journal of the International Association for the Study of the Liver (2018)

This study provides evidence for the role of PNPLA3 as a determinant of portal NAFLD localization and severity of portal fibrosis in children and adolescents, the risk variant being associated with an impaired hepatic retinol metabolism.

Keyphrases

liver fibrosis
emergency department
intensive care unit
insulin resistance
type diabetes
gene expression
skeletal muscle
dna methylation
high fat diet induced