ALKBH5-mediated m 6 A demethylation ameliorates extracellular matrix deposition in cutaneous pathological fibrosis.

Ruoqing XuEn YangHsin LiangShenying LuoYunhan LiuYimin KhoongHaizhou LiXin HuangYixuan ZhaoTao Zan

Published in: Clinical and translational medicine (2024)

Our study identified ALKBH5 as an endogenous suppressor of pathological ECM deposition, contributing to the development of a reprogrammed m6A-targeted therapy for HTSs.

Keyphrases

extracellular matrix
mouse model
liver fibrosis