Catechol-O-methyltransferase (COMT) polymorphism predicts rapid gait speed changes in healthy older adults.
Briana N SpragueAndrea L RossoXiaonan ZhuNicolaas I BohnenCaterina RosanoPublished in: Journal of the American Geriatrics Society (2021)
Greater prefrontal DA measured with COMT polymorphism may facilitate short-term adaptation to rapid walking demands that are lost over time. Studies should examine whether these effects are long-term and the underlying mechanistic pathways.