Stimulation of Immune Checkpoint Molecule B and T-Lymphocyte Attenuator Alleviates Experimental Crescentic Glomerulonephritis.

Paul DiefenhardtMarie BraumannThomas SchömigBastian Trinsch Claudio Sierra GonzalezJanine Becker-GototLinus A Völker Lioba Ester Amrei M MandelDaniel HawigerAli T Abdallah Bernhard Schermer Heike Göbel Paul Thomas Brinkkoetter Christian Kurts Thomas Benzing Sebastian Brähler

Published in: Journal of the American Society of Nephrology : JASN (2023)

In a model of crescentic GN, BTLA signaling effectively restrained nephritogenic Th1 cells and promoted regulatory T cells. Suppression of T-cell-mediated inflammation by BTLA stimulation may prove relevant for a broad range of conditions involving acute GN.

Keyphrases

regulatory t cells
induced apoptosis
dendritic cells
oxidative stress
liver failure
cell cycle arrest
respiratory failure
endoplasmic reticulum stress
drug induced
mouse model
cell death
intensive care unit
cell proliferation
mechanical ventilation
acute respiratory distress syndrome