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Stimulation of Immune Checkpoint Molecule B and T-Lymphocyte Attenuator Alleviates Experimental Crescentic Glomerulonephritis.

Paul DiefenhardtMarie BraumannThomas SchömigBastian TrinschClaudio Sierra GonzalezJanine Becker-GototLinus A VölkerLioba EsterAmrei M MandelDaniel HawigerAli T AbdallahBernhard SchermerHeike GöbelPaul Thomas BrinkkoetterChristian KurtsThomas BenzingSebastian Brähler
Published in: Journal of the American Society of Nephrology : JASN (2023)
In a model of crescentic GN, BTLA signaling effectively restrained nephritogenic Th1 cells and promoted regulatory T cells. Suppression of T-cell-mediated inflammation by BTLA stimulation may prove relevant for a broad range of conditions involving acute GN.
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