Oxidative Stress in Brain in Amnestic Mild Cognitive Impairment.
David Allan ButterfieldPublished in: Antioxidants (Basel, Switzerland) (2023)
Amnestic mild cognitive impairment (MCI), arguably the earliest clinical stage of Alzheimer disease (AD), is characterized by normal activities of daily living but with memory issues but no dementia. Oxidative stress, with consequent damaged key proteins and lipids, are prominent even in this early state of AD. This review article outlines oxidative stress in MCI and how this can account for neuronal loss and potential therapeutic strategies to slow progression to AD.
Keyphrases
- mild cognitive impairment
- oxidative stress
- cognitive decline
- dna damage
- ischemia reperfusion injury
- diabetic rats
- induced apoptosis
- white matter
- working memory
- resting state
- heat shock
- risk assessment
- blood brain barrier
- functional connectivity
- climate change
- signaling pathway
- endoplasmic reticulum stress
- heat shock protein
- human health
- brain injury