Natural killer cell activation by respiratory syncytial virus-specific antibodies is decreased in infants with severe respiratory infections and correlates with Fc-glycosylation.
Elisabeth A van ErpAnke J LakerveldErik de GraafMads Delbo LarsenRutger M ScheppAgnes L Hipgrave EderveenInge Ml AhoutCornelis Am de HaanManfred WuhrerWillem LuytjesGerben FerwerdaGestur VidarssonPuck B van KasterenPublished in: Clinical & translational immunology (2020)
Our results suggest that Fc-dependent antibody function and quality, exemplified by NK cell activation and glycosylation, contribute to protection against severe RSV disease and warrant further studies to evaluate the potential of using these properties to evaluate and improve the efficacy of novel vaccines.