Palladium-Catalyzed E -Selective Oxidative Amination of Aromatic Amine with 3-Butenoic Acid.

A palladium-catalyzed oxidative amination of inactive olefins with an aromatic amine was developed using a copper acetate oxidant to yield corresponding secondary and tertiary enamines in moderate to good yields. This new procedure outlines an efficient approach for the construction of enamine skeletons.