A new 7',9-epoxylignan from the stems of Salacia chinensis.

Nhan Trung NguyenTruc T T DuongPhu Hoang Dang Hai Xuan NguyenTho H LeTruong N V DoThinh D LeTu H TranMai Thanh Thi Nguyen

Published in: Natural product research (2021)

Bioactivity-guided isolation of the CHCl3-soluble fraction of the stems of Salacia chinensis L. (Celastraceae) was carried out to obtain a new 7',9-epoxylignan (1) and three 7,9':7',9-diepoxylignans (2-4). The absolute configuration of 1 was elucidated based on NMR and ECD spectroscopic data interpretation. All isolated lignans showed intermediate α-glucosidase inhibitory activity with the IC50 values ranging from 28.5 to 85.6 µM.

Keyphrases

molecular docking
magnetic resonance
high resolution
electronic health record
big data
solid state
artificial intelligence