The Role of Farnesoid X Receptor in Accelerated Liver Regeneration in Rats Subjected to ALPPS.

Noemi DaradicsPim B OlthofAndras BudaiMichal HegerThomas M van GulikAndras FulopAttila Szijarto

Published in: Current oncology (Toronto, Ont.) (2021)

Our study elaborates on a possible linkage between BA-induced Fxr signaling and accelerated liver regeneration induced by ALPPS in rats. ALPPS could trigger liver regeneration via intestinal Fxr signaling cascades instead of hepatic Fxr signaling, thereby deviating from the mechanism of BA-mediated regeneration following one-stage hepatectomy.

Keyphrases

stem cells
wound healing
genome wide
high glucose
diabetic rats
endothelial cells
human immunodeficiency virus
hiv infected
antiretroviral therapy