R230C but not - 565C/T variant of the ABCA1 gene is associated with type 2 diabetes in Mexicans through an effect on lowering HDL-cholesterol levels.
A Ochoa-GuzmánH Moreno-MacíasD Guillén-QuinteroO Chávez-TalaveraM L Ordoñez-SánchezY Segura-KatoV OrtízE Díaz-DíazL Muñoz-HernándezA GarcíaO Pérez-MéndezA Zentella-DehesaC A Aguilar-SalinasMaría Teresa Tusié-LunaPublished in: Journal of endocrinological investigation (2020)
The ABCA1 rs9282541 (R230C) allele is associated with T2D in Mexicans through its effect on lowering HDL-c levels. This is the first report demonstrating that HDL-c levels act as an intermediate factor between an ABCA1 variant and T2D.