Iron-Rich Semiconducting Polymer Dots for The Combination of Ferroptosis-Starvation And Phototherapeutic Cancer Therapy.

Chemodynamic therapy (CDT) has emerged as an outstanding antitumor therapeutic method due to its selectivity and utilization of tumor microenvironment (TME). However, there are still unmet requirements to achieve a high antitumor efficiency, including the tumor-accumulation of catalyst and enrichment of reactants of Fenton reaction. Here, we reported an iron-loaded semiconducting polymer dots modified with glucose oxidase (Pdots@Fe@GOx) to deliver iron ions into tumor tissues and in situ generation of hydrogen peroxide in tumor. On one hand, Pdots@Fe@GOx converts glucose to gluconic acid and H 2 O 2 in tumor, which not only consumes glucose of tumor cells, but also provides the H 2 O 2 for the following Fenton reaction. On the other hand, the Pdots@Fe@GOx delivers active iron ions in tumor to perform CDT with the combination of the generated H 2 O 2 . In addition, the Pdots@Fe@GOx has both photothermal and photodynamic effects under the irradiation of near-infrared (NIR) laser, which could improve and compensate the CDT effect to kill cancer cells. This Pdots@Fe@GOx based multiple-mode therapeutic strategy has successfully achieved a synergistic anticancer effect with minimal side effects and has the potential to be translated into pre-clinical setting for tumor therapy. This article is protected by copyright. All rights reserved.