Mast cell infiltration associated with loss of interstitial cells of Cajal and neuronal degeneration in achalasia.

Zu-Qiang LiuWei-Feng ChenYun WangXiao-Yue XuYi-Gang ZengDustin Lee DillonJing ChengMei-Dong XuYun-Shi ZhongYi-Qun ZhangLi-Qing YaoPing Hong ZhouQuan-Lin Li

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2019)

In patients with achalasia, mast cell infiltration in the LES muscle is increased, in association with loss of ICCs and neuronal degeneration. Mast cells may thereby play a crucial role in the development of achalasia.

Keyphrases

induced apoptosis
cell cycle arrest
cerebral ischemia
skeletal muscle
oxidative stress
endoplasmic reticulum stress
cell death
cell proliferation
blood brain barrier
brain injury