Optimal combinations of CSF biomarkers for predicting cognitive decline and clinical conversion in cognitively unimpaired participants and mild cognitive impairment patients: A multi-cohort study.

Gemma SalvadóVictoria LarssonKarly A CodyNicholas C CullenErin M JonaitisErik StomrudGwendlyn KollmorgenNorbert WildSebastian PalmqvistShorena JanelidzeNiklas Mattsson-CarlgrenHenrik ZetterbergKaj BlennowSterling C JohnsonRik OssenkoppeleOskar Hansson

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)

P-tau/Aβ42 is sufficient for predicting progression in AD, with very high accuracy. Adding NfL improves the prediction of all-cause dementia conversion and cognitive decline.

Keyphrases

cognitive decline
mild cognitive impairment
end stage renal disease
ejection fraction
newly diagnosed
peritoneal dialysis
cerebrospinal fluid