Adjunctive use of p16 immunohistochemistry for optimizing management of CIN lesions in a high-risk human papillomavirus-positive population.
Renée M F EbischL Lucia RijstenbergGilda Ghazi SoltaniJudith van der HorstJudith E M VedderMeyke HermsenRemko P BosgraafLeon F A G MassugerChris J L M MeijerDaniëlle A M HeidemanFolkert J van KemenadeWillem J G MelchersRuud L M BekkersAlbert G SiebersJohan BultenPublished in: Acta obstetricia et gynecologica Scandinavica (2022)
This study shows that adjunctive use of p16 immunohistochemistry to H&E morphology reduces the number of CIN1 and CIN2 classifications with a proportional increase in no CIN and CIN3 diagnoses, compared with standard H&E-based CIN diagnosis alone. The pathologists felt more confident in classifying the material with H&E and p16 immunohistochemistry than by using H&E alone, particularly during assessment of small biopsies. Adjunctive use of p16 immunohistochemistry to standard H&E assessment of CIN would be valuable for the diagnostic accuracy, thereby optimizing CIN management and possibly decreasing overtreatment.
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