Decreased Suppression and Increased Phosphorylated STAT3 in Regulatory T Cells are Associated with Benefit from Adjuvant PD-1 Blockade in Resected Metastatic Melanoma.

David M WoodsRupal RamakrishnanAndressa S LainoAnders BerglundKelly WaltonBrian C BettsJeffrey S Weber

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

These results demonstrate that induction of pSTAT3, reduced suppressive function, and a paradoxical increase in Treg proliferation are novel correlates of patient benefit from PD-1 blockade.

Keyphrases

regulatory t cells
dendritic cells
early stage
case report
lymph node
signaling pathway
cell proliferation
immune response