Urate-induced epigenetic modifications in myeloid cells.

M BadiiO I GaalM C CleophasV KlückR DavarE HabibiS T KeatingB NovakovicM M HelsenN DalbethL K StampD Macartney-CoxsonA J Phipps-GreenH G StunnenbergC A DinarelloT R MerrimanM G NeteaT O CrişanLeo A B Joosten

Published in: Arthritis research & therapy (2021)

Urate alters the epigenetic landscape in selected human monocytes or whole blood of people with hyperuricemia compared to normouricemia. Both histone modifications and DNA methylation show differences depending on urate exposure. Subject to replication and validation, epigenetic changes in myeloid cells may be a therapeutic target in gout.

Keyphrases

dna methylation
induced apoptosis
gene expression
genome wide
cell cycle arrest
bone marrow
endothelial cells
uric acid
endoplasmic reticulum stress
oxidative stress
signaling pathway
single cell
cell death
immune response
cell proliferation
peripheral blood
diabetic rats
drug induced