Circadian rhythm is a master process observed in nearly every type of cell throughout the body, and it macroscopically regulates daily physiology. Recent clinical trials have revealed the effects of circadian variation on the incidence, pathophysiological processes, and prognosis of acute ischemic stroke. Furthermore, core clock genes, the cell-autonomous pacemakers of the circadian rhythm, affect the neurovascular unit-composing cells in a nonparallel manner after the same pathophysiological processes of ischemia/reperfusion. In this review, we discuss the influence of circadian rhythms and clock genes on each type of neurovascular unit cell in the pathophysiological processes of acute ischemic stroke.
Keyphrases
- acute ischemic stroke
- single cell
- clinical trial
- cell therapy
- atrial fibrillation
- genome wide
- induced apoptosis
- stem cells
- gene expression
- physical activity
- blood pressure
- risk factors
- dna methylation
- signaling pathway
- cell death
- blood brain barrier
- oxidative stress
- phase ii
- genome wide identification
- cerebral ischemia