The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome.
Maria Consiglia TrottaRosa MaistoFrancesca GuidaSerena BoccellaLivio LuongoCornel BaltaGiovanbattista D'AmicoHildegard HermanAnca HermeneanClaudio BucoloMichele D'AmicoPublished in: PloS one (2019)
These data suggest that the systemic treatment of diabetic C57BL6J mice with BHB activates retinal HCA2 and inhibits local damage.