Diagnostic accuracy of cell-free DNA in maternal blood in detecting chromosomal anomalies in twin pregnancies: systematic review and meta-analysis.

L Della ValleM PiergianniA KhalilA NovelliGiuseppe RizzoI MappaSmriti PrasadB MatarrelliV GattaL StuppiaG PaganiM E FlaccoF D'Antonio

Published in: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (2024)

cfDNA has a high diagnostic accuracy in detecting Trisomy 18 and 21 in twin pregnancies, irrespective of chorionicity. Accuracy in the detection of Trisomy 13 and SCA was limited by the small number of affected cases and the difficulties in the confirmation of false negative cases in case of SCA and requires confirmation in larger studies. This article is protected by copyright. All rights reserved.

Keyphrases

pregnancy outcomes
preterm birth
gestational age
birth weight
copy number
pregnant women
loop mediated isothermal amplification
physical activity