Nicotine inhibits osteogenic differentiation of human periodontal ligament cells under cyclic tensile stress through canonical Wnt pathway and α7 nicotinic acetylcholine receptor.

W YuB HuX ShiZ CaoM RenZ HeJ LinH DengRongdang Hu

Published in: Journal of periodontal research (2018)

These results indicate that nicotine prevents the increased osteogenic potential of hPDLCs induced by cyclic tensile stress by binding to an α7 nicotinic acetylcholine receptor and activating the canonical Wnt pathway.

Keyphrases

induced apoptosis
cell proliferation
smoking cessation
stem cells
endothelial cells
mesenchymal stem cells
signaling pathway
cell cycle arrest
bone marrow
stress induced
binding protein
oxidative stress
mouse model
risk assessment
cell death
pi k akt
climate change