Anti-drug antibodies anti-trastuzumab in the treatment of breast cancer.

Ivette Mourani PadrónJonathan González GarcíaRuth Tramontani Ramos Isaac Ceballos LenzaFernando Gutiérrez Nicolás

Published in: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2020)

This study may be the first ever conducted under usual clinical practice conditions to detect the presence of ADA-Tras in patients with non-metastatic HER2-positive breast cancer. We have wanted to show the antibodies anti-trastuzumab determination as a possible tool that would enable comparison of potential differences in immunogenic behavior between trastuzumab and its biosimilars.

Keyphrases

positive breast cancer
epidermal growth factor receptor
clinical practice
metastatic breast cancer
squamous cell carcinoma
small cell lung cancer
young adults
combination therapy
human health
replacement therapy
clinical evaluation