Freshwater Clam Extract Mitigates Neuroinflammation and Amplifies Neurotrophic Activity of Glia: Insights from In Vitro Model of Neurodegenerative Pathomechanism.
Muh-Shi LinShu-Mei ChenKuo-Feng HuaWei-Jung ChenCho-Chen HsiehChai-Ching LinPublished in: Journal of clinical medicine (2022)
Evidence reveals that FCE is capable of stabilizing reactive glia, as demonstrated by reduced neuroinflammation, oxidative stress, the increased release of neurotrophic factors and the inhibition of apoptosis, which provides therapeutic insight into neurodegenerative diseases, including PD.
Keyphrases
- oxidative stress
- lipopolysaccharide induced
- lps induced
- traumatic brain injury
- cognitive impairment
- cerebral ischemia
- ischemia reperfusion injury
- diabetic rats
- dna damage
- induced apoptosis
- inflammatory response
- endoplasmic reticulum stress
- cell cycle arrest
- radiation induced
- cell death
- radiation therapy
- heat shock
- brain injury