Sirtuin 5-Mediated Lysine Desuccinylation Protects Mitochondrial Metabolism Following Subarachnoid Hemorrhage in Mice.
Zhi-Peng XiaoTao LvPin-Pin HouAnatol ManaenkoYuandong LiuYichao JinLi GaoFeng JiaYang TianPei-Ying LiArne P NeyrinckQin HuXiao-Hua ZhangPublished in: Stroke (2021)
Protein lysine succinylation is a biochemical hallmark of metabolic crisis after SAH, and disruption of lysine succinylation through activation of Sirt5 might be a promising therapeutic strategy for the treatment of SAH.