Phase II Trial of Imatinib Plus Binimetinib in Patients With Treatment-Naive Advanced Gastrointestinal Stromal Tumor.
Ping ChiLi-Xuan QinBastien NguyenCiara M KellySandra P D' AngeloMark A DicksonMrinal M GounderMary L KeohanSujana MovvaBenjamin A NacevEvan RosenbaumKatherine A ThorntonAimee M CragoSam YoonGary A UlanerRandy YehMoriah MartindaleHaley T PhelanMatthew D BiniakewitzSarah WardaCindy J LeeMichael F BergerSamuel SingerSinchun HwangYu ChenCristina R AntonescuWilliam D TapPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)
The study met the primary end point. The combination of imatinib and binimetinib is effective with manageable toxicity and warrants further evaluation in direct comparison with imatinib in frontline treatment of GIST.