High-Frequency Oscillations in the Pallidum: A Pathophysiological Biomarker in Parkinson's Disease?
Luke A JohnsonJoshua E AmanYing YuDavid Escobar SanabriaJing WangMeghan HillRajiv DharnipragadaRemi PatriatMark FiecasLaura LiLauren E SchrockScott E CooperMatthew D JohnsonMichael C ParkNoam HarelJerrold L VitekPublished in: Movement disorders : official journal of the Movement Disorder Society (2021)
Our findings provide evidence in support of the hypothesis that exaggerated, movement-modulated high-frequency oscillations in the GPi are pathophysiological features of PD. These findings suggest that the functional role(s) of high-frequency oscillations may differ between the STN and GPi and motivate additional investigations into their relationship to motor control in normal and diseased states.