Metabolic stress in cancer cells induces immune escape through a PI3K-dependent blockade of IFNγ receptor signaling.

Koen A MarijtMarjolein SluijterLaura BlijlevenSofie H TolmeijerFerenc A ScheerenSjoerd H van der BurgThorbald van Hall

Published in: Journal for immunotherapy of cancer (2019)

These data revealed a strong impact of metabolic stress on the presentation of tumor antigens by MHC class I and suggest that this type of tumor escape takes place at hypoxic areas even during times of active T cell immunity and IFNy release.

Keyphrases

dendritic cells
immune response
stress induced
electronic health record
big data
artificial intelligence
data analysis