Evolution of Genomic and T-cell Repertoire Heterogeneity of Malignant Pleural Mesothelioma Under Dasatinib Treatment.

Runzhe Chen Won-Chul LeeJunya FujimotoJun LiXin HuReza MehranDavid RiceStephen G SwisherBoris SepesiHai T TranChi-Wan ChowLatasha D LittleCurtis GumbsCara L Haymaker John Victor HeymachIgnacio I WistubaJiun-Kae Jack LeeP Andrew FutrealJianhua ZhangAlexandre Reuben Anne S TsaoJianjun Zhang

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Despite the homogeneous genomic landscape, the TCR repertoire is extremely heterogeneous in MPM. Dasatinib may potentially induce T-cell response leading to improved survival.

Keyphrases

single cell
copy number
chronic myeloid leukemia
high throughput sequencing
regulatory t cells
immune response
dna methylation
smoking cessation