Associations between Pretreatment Body Composition Features and Clinical Outcomes among Patients with Metastatic Clear Cell Renal Cell Carcinoma Treated with Immune Checkpoint Blockade.

Yasser Ged Alejandro Sanchez Sujata Patil Andrea Knezevic Emily Stein Stacey Petruzella Kate Weiss Cihan Duzgol Joshua Chaim Oguz Akin Marina Mourtzakis Michael T Paris Jessica M Scott Fengshen Kuo Ritesh R Kotecha Abraham Ari Hakimi Chung-Han Lee Robert J Motzer Martin H Voss Helena Furberg

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Our findings highlight the relevance of skeletal muscle in the BMI paradox. Future studies should investigate if addressing low skeletal muscle in metastatic patients treated with ICB can improve survival.

Keyphrases

body composition
skeletal muscle
squamous cell carcinoma
small cell lung cancer
resistance training
insulin resistance
bone mineral density
body mass index
current status
type diabetes
free survival
newly diagnosed
postmenopausal women
high intensity