Brominated Depsidones with Antibacterial Effects from a Deep-Sea-Derived Fungus Spiromastix sp.
Zequan HuangDong LiuShang ChenJinwei RenCheng-Hai GaoZhiyong LiAili FanWen-Han LinPublished in: Marine drugs (2024)
Eleven new brominated depsidones, namely spiromastixones U-Z5 ( 1 - 11 ) along with five known analogues ( 12 - 16 ), were isolated from a deep-sea-derived fungus Spiromastix sp. through the addition of sodium bromide during fermentation. Their structures were elucidated by extensive analysis of the spectroscopic data including high-resolution MS and 1D and 2D NMR data. Compounds 6 - 10 and 16 exhibited significant inhibition against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) with MIC values ranging from 0.5 to 2.0 μM. Particularly, tribrominated 7 displayed the strongest activity against MRSA and VRE with a MIC of 0.5 and 1.0 μM, respectively, suggesting its potential for further development as a new antibacterial agent.
Keyphrases
- methicillin resistant staphylococcus aureus
- high resolution
- staphylococcus aureus
- mass spectrometry
- molecular docking
- electronic health record
- big data
- silver nanoparticles
- magnetic resonance
- multiple sclerosis
- ms ms
- gram negative
- machine learning
- cystic fibrosis
- pseudomonas aeruginosa
- escherichia coli
- data analysis
- solid state
- liquid chromatography