Acanthoic acid suppresses lipin1/2 via TLR4 and IRAK4 signalling pathways in EtOH- and lipopolysaccharide-induced hepatic lipogenesis.

Jian SongXin HanYou-Li YaoYa-Mei LiJing ZhangDan-Yang ShaoLi-Shuang HouYing FanShun-Zong SongLi-Hua LianJi-Xing NanYan-Ling Wu

Published in: The Journal of pharmacy and pharmacology (2018)

Our data demonstrated that AA might modulate hepatic fibrosis and lipid deposition in HSC-T6 cell stimulated with ethanol combined with LPS by decreasing lipin1/2 via TLR4 and IRAK4 signalling pathways, and AA might be considered as a potential therapeutic candidate for alcoholic liver disease.

Keyphrases

inflammatory response
lipopolysaccharide induced
toll like receptor
signaling pathway
electronic health record
big data
nuclear factor
metabolic syndrome
deep learning