Digitoxin for Airway Inflammation in Cystic Fibrosis: Preliminary Assessment of Safety, Pharmacokinetics, and Dose Finding.
Pamela L ZeitlinMarie Diener-WestKaren A CallahanSeakwoo LeeC Conover TalbotBette PollardMichael P BoyleNoah LechtzinPublished in: Annals of the American Thoracic Society (2018)
At a dose of 0.1 mg daily for 28 days, digitoxin was safe for adults with CF lung disease, but it did not achieve a significant decrease in sputum inflammatory markers. Clinical trial registered with www.clinicaltrials.gov (NCT00782288).