Ischemic stroke in PAR1 KO mice: Decreased brain plasmin and thrombin activity along with decreased infarct volume.

Efrat Shavit-SteinEkaterina MindelShany Guly GofritJoab ChapmanNicola Maggio

Published in: PloS one (2021)

PAR1 KO mice have smaller infarcts, with lower thrombin and plasmin activity levels. These findings may suggest that modulation of PAR1 is a potential target for future pharmacological treatment of ischemic stroke.

Keyphrases

high fat diet induced
atrial fibrillation
resting state
heart failure
current status
multiple sclerosis
adipose tissue
risk assessment
brain injury
combination therapy
subarachnoid hemorrhage
blood brain barrier
climate change
replacement therapy