Acid-gastric antisecretory effect of the ethanolic extract from Arctium lappa L. root: role of H+, K+-ATPase, Ca2+ influx and the cholinergic pathway.
Luisa Mota da SilvaLigia de Moura BurciSandra CrestaniPriscila de SouzaRita de Cássia Melo Vilhena de Andrade Fonseca da SilvaNessana DartoraLauro Mera de SouzaThales Ricardo CiprianiJosé Eduardo da Silva-SantosEunice AndréMaria Fernanda de Paula WernerPublished in: Inflammopharmacology (2017)
Our results reinforce the gastric antisecretory properties of preparations obtained from Arctium lappa, and indicate that the mechanisms involved in EET antisecretory effects include a moderate reduction of the H+, K+-ATPase activity associated with inhibitory effects on calcium influx and of cholinergic pathways in the stomach muscle.
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