Exploring the Mechanism of Skeletal Muscle in a Tacrolimus-Induced Posttransplantation Diabetes Mellitus Model on Gene Expression Profiles.

Chenlei ZhengCheng WangTan ZhangDing LiXiao-Feng NiJian-Hu LinLinxiao Sun Bi-Cheng Chen

Published in: Journal of diabetes research (2020)

This study explored the molecular mechanism of muscle atrophy in a tacrolimus-induced PTDM model by bioinformatics analyses. We identified 275 DEGs and identified significant biomarkers for predicting the development and progression of tacrolimus-induced PTDM.

Keyphrases

skeletal muscle
high glucose
diabetic rats
oxidative stress
insulin resistance
type diabetes
endothelial cells
gene expression
genome wide
adipose tissue
transcription factor