A Network Pharmacology-Based Strategy For Predicting Active Ingredients And Potential Targets Of LiuWei DiHuang Pill In Treating Type 2 Diabetes Mellitus.

Dan HeJian-Hua HuangZhe-Yu ZhangQing DuWei-Jun PengRong YuSi-Fang ZhangShui-Han ZhangYu-Hui Qin

Published in: Drug design, development and therapy (2019)

Based on a systematic network pharmacology approach, our works successfully predict the active ingredients and potential targets of LWDH Pill for application to T2DM and helps to illustrate mechanism of action on a comprehensive level. This study provides identify key genes and pathway associated with the prognosis and pathogenesis of T2DM from new insights, which also demonstrates a feasible method for the research of chemical basis and pharmacology in LWDH Pill.

Keyphrases

glycemic control
human health
gene expression
risk assessment
skeletal muscle
climate change
weight loss
transcription factor
genome wide analysis