Phthalates are detected in the follicular fluid of adolescents and oocyte donors with associated changes in the cumulus cell transcriptome.

Dilan Gokyer Mary J LawsAnna KleinhansJoan K RileyJodi A Flaws Elnur Babayev

Published in: bioRxiv : the preprint server for biology (2024)

Adolescents undergoing fertility preservation cycles demonstrate higher levels of phthalate metabolites in their follicular fluid compared to oocyte donors. Phthalate metabolite levels in FF are associated with higher AFC levels in oocyte donors. Higher phthalate levels in FF are associated with alterations in the cumulus cells transcriptome in adolescents.

Keyphrases

young adults
single cell
physical activity
gene expression
rna seq
induced apoptosis
genome wide
stem cells
kidney transplantation
cell cycle arrest
mesenchymal stem cells
oxidative stress
signaling pathway
cell proliferation
endoplasmic reticulum stress
dna methylation
pi k akt