B-Cell Receptor Signaling Is Thought to Be a Bridge between Primary Sjogren Syndrome and Diffuse Large B-Cell Lymphoma.
Leila MohammadnezhadMojtaba Shekarkar AzgomiMarco Pio La MannaGiuliana GugginoCirino BottaFrancesco DieliNadia CaccamoPublished in: International journal of molecular sciences (2023)
Primary Sjogren syndrome (pSS) is the second most common autoimmune disorder worldwide, which, in the worst scenario, progresses to Non-Hodgkin Lymphoma (NHL). Despite extensive studies, there is still a lack of knowledge about developing pSS for NHL. This study focused on cells' signaling in pSS progression to the NHL type of diffuse large B-cell lymphoma (DLBCL). Using bulk RNA and single cell analysis, we found five novel pathologic-independent clusters in DLBCL based on cells' signaling. B-cell receptor (BCR) signaling was identified as the only enriched signal in DLBCL and pSS peripheral naive B-cells or salivary gland-infiltrated cells. The evaluation of the genes in association with BCR has revealed that targeting CD79A , CD79B , and LAMTOR4 as the shared genes can provide novel biomarkers for pSS progression into lymphoma.
Keyphrases
- diffuse large b cell lymphoma
- epstein barr virus
- induced apoptosis
- cell cycle arrest
- single cell
- acute lymphoblastic leukemia
- healthcare
- multiple sclerosis
- endoplasmic reticulum stress
- oxidative stress
- gene expression
- squamous cell carcinoma
- high throughput
- lymph node
- chronic myeloid leukemia
- pi k akt
- cancer therapy
- binding protein
- antiretroviral therapy