Cooperative antitumor activities of carnosic acid and Trastuzumab in ERBB2+ breast cancer cells.

Carolina D'AlesioGrazia BelleseMaria Cristina GaglianiCinzia AielloElena GrasselliGianluca MarcocciAngela BisioSara TavellaTiziana DanieleKatia CortesePatrizio Castagnola

Published in: Journal of experimental & clinical cancer research : CR (2017)

Our data demonstrate the cooperation between CA and Tz in inhibiting cell migration and survival of ERBB2+ BC cells that warrant further studies to establish if CA or CA derivatives may be useful in vivo in the treatment of ERBB2+ cancers.

Keyphrases

cell migration
tyrosine kinase
breast cancer cells
induced apoptosis
epidermal growth factor receptor
protein kinase
signaling pathway
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
free survival
case control
young adults
metastatic breast cancer
replacement therapy