Gas6/Axl signaling attenuates alveolar inflammation in ischemia-reperfusion-induced acute lung injury by up-regulating SOCS3-mediated pathway.

Chung-Kan PengChin-Pyng WuJr-Yu LinShih-Chi PengChien-Hsing LeeKun-Lun HuangChih-Hao Shen

Published in: PloS one (2019)

Gas6 up-regulates phosphorylation of Axl on alveolar epithelium in IR-ALI. The Gas6/Axl signaling activates the SOCS3-mediated pathway and attenuates IR-related inflammation and injury.

Keyphrases

tyrosine kinase
room temperature
oxidative stress
carbon dioxide
protein kinase
drug induced