Statistical methods for testing X chromosome variant associations: application to sex-specific characteristics of bipolar disorder.
William A JonsColin L ColbySusan L McElroyMark A FryeJoanna M BiernackaStacey J WinhamPublished in: Biology of sex differences (2019)
X chromosome association studies should employ methods which account for its unique biology. Future work is needed to validate the identified associations with BD, to formally assess the performance of both approaches under different true genetic architectures, and to apply these approaches to study sex differences in other conditions.