TRIPODD: a Novel Fluorescence Imaging Platform for In Situ Quantification of Drug Distribution and Therapeutic Response.

Nathan P McMahonAllison SolankiLei G WangAntonio R MontañoJocelyn A JonesKimberley S SamkoeKenneth M TichauerSummer L Gibbs

Published in: Molecular imaging and biology (2021)

Herein, we demonstrated the utility of TRIPODD as a powerful imaging platform capable of interpreting tumor heterogeneity for a mechanistic understanding of therapeutic response and resistance through quantification of drug target availability and proteomic response with preserved spatial context at single-cell resolution.

Keyphrases

fluorescence imaging
single cell
high throughput
photodynamic therapy
rna seq
high resolution
emergency department
mass spectrometry
drug induced