Mammary carcinoma: comparative oncology between small animals and humans - new therapeutic tools.

The poor outcomes associated with mammary carcinomas in dogs and cats in terms of locoregional recurrence, distant metastasis, and survival, highlight the need for better management of mammary cancers in small animals. By contrast, the outcomes of women with breast cancer have dramatically improved during the last 10 years, notably thanks to new therapeutic strategies. The aim of this article was to imagine what could be the future of therapy for dogs and cats with mammary carcinomas if it became inspired from current practices in human breast cancer. This article focuses on the importance of taking into account cancer stage and cancer subtypes in therapeutic plans, on locoregional treatments (surgery, radiation therapy), new developments in endocrine therapy, chemotherapy, PARP inhibitors, and immunotherapy. Ideally, multimodal treatment regimens would be chosen according to cancer stage and cancer subtypes, and according to predictive factors that are still to be defined. This article is protected by copyright. All rights reserved.