Topical therapy with negative allosteric modulators of the calcium-sensing receptor (calcilytics) for the management of asthma: the beginning of a new era?
Daniela RiccardiJeremy P T WardPolina L YarovaLuke J JanssenTak Hong LeeSun YingChris J CorriganPublished in: The European respiratory journal (2022)
In this review article we present the evidence to date supporting the role of the calcium-sensing receptor (CaSR) as a key, pluripotential molecular trigger for asthma and speculate on the likely benefits of topical therapy of asthma with negative allosteric modulators of the CaSR: calcilytics.